No. of Recommendations: 4
I normally don't post Topol, because he's difficult to read and understand sometimes. But this is a point I've suspected for some time.
Eric Topol @erictopol.bsky.social
A benefit of prior vaccination when there's a breakthrough infection: putting the brakes on a maladaptive innate immune response
Editor’s summary
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines were instrumental in curbing the COVID-19 pandemic, with the benefit of vaccination primarily attributed to the adaptive immune response. Although it is well established that antibodies and T cells against SARS-CoV-2 prevent severe disease, the role of the innate immune system should not be disregarded. Here, Chan et al. demonstrated precisely why.
The authors compared individuals infected with SARS-CoV-2 during the Delta wave with or without prior vaccination. They found that prior vaccination tamped down excessive inflammatory responses often associated with more severe disease, particularly in monocytes and natural killer cells. The authors further validated these findings in a separate cohort during a different wave of infection. These data suggest that vaccination may influence the innate immune response, and consequently disease severity, during a SARS-CoV-2 breakthrough infection. —Courtney Malo
https://www.science.org/doi/10.1126/scitranslmed.a...It sounds like the vaccines help delay an immune response that won't combat the virus, thus lessening the time for adaptation, and inhibiting damaging inflammation. The abstract also says there's a female specific advantage. !! It's a Chinese conspiracy of women at the Wuhan lab! Men of the world UNITE! :)
